William Sinko: search on Z-Library

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1

The effect of cell culture conditions on saquinavir transport through, and interactions with, MDCKII cells overexpressing hMDR1

Gregory C. Williams, Gregory T. Knipp, Patrick J. Sinko

Journal:

Journal of Pharmaceutical Sciences

Year:

2003

Language:

english

File:

PDF, 222 KB

english, 2003

2

Utility of pharmacodynamic measures for assessing the oral bioavailability of peptides. 1. Administration of recombinant salmon calcitonin in rats

Patrick J. Sinko, Curtis L. Smith, Laura T. McWhorter, William Stern, Erik Wagner, James P. Gilligan

Journal:

Journal of Pharmaceutical Sciences

Year:

1995

Language:

english

File:

PDF, 623 KB

english, 1995

3

Applying Molecular Dynamics Simulations to Identify Rarely Sampled Ligand-bound Conformational States of Undecaprenyl Pyrophosphate Synthase, an Antibacterial Target

William Sinko, César de Oliveira, Sarah Williams, Adam Van Wynsberghe, Jacob D. Durrant, Rong Cao, Eric Oldfield, J. Andrew McCammon

Journal:

Chemical Biology & Drug Design

Year:

2011

Language:

english

File:

PDF, 728 KB

english, 2011

4

Regional Differences in Intestinal Spreading and pH Recovery and the Impact on Salmon Calcitonin Absorption in Dogs

Yong-Hee Lee, Barbara A. Perry, John P. Sutyak, William Stern, Patrick J. Sinko

Journal:

Pharmaceutical Research

Year:

2000

Language:

english

File:

PDF, 634 KB

english, 2000

5

Impact of Regional Intestinal pH Modulation on Absorption of Peptide Drugs: Oral Absorption Studies of Salmon Calcitonin in Beagle Dogs

Yong-Hee Lee, Barbara A. Perry, Stacy Labruno, HeeSang Lee, William Stern, Lisa M. Falzone, Patrick J. Sinko

Journal:

Pharmaceutical Research

Year:

1999

File:

PDF, 1.25 MB

1999

6

Tumor-targeted bioconjugate based delivery of camptothecin: design, synthesis and in vitro evaluation

Pankaj V. Paranjpe, Yu Chen, Vladyslav Kholodovych, William Welsh, Stanley Stein, Patrick J. Sinko

Journal:

Journal of Controlled Release

Year:

2004

Language:

english

File:

PDF, 866 KB

english, 2004

7

Molecular targeting of drug delivery systems to ovarian cancer by BH3 and LHRH peptides

S.S Dharap, B Qiu, G.C Williams, P Sinko, S Stein, T Minko

Journal:

Journal of Controlled Release

Year:

2003

Language:

english

File:

PDF, 651 KB

english, 2003

8

Oral absorption of the HIV protease inhibitors: a current update

Gregory C. Williams, Patrick J. Sinko

Journal:

Advanced Drug Delivery Reviews

Year:

1999

Language:

english

File:

PDF, 352 KB

english, 1999

9

The wake-promoting effects of hypocretin-1 are attenuated in old rats

Stephen R. Morairty, Jonathan Wisor, Kristy Silveira, William Sinko, Thomas S. Kilduff

Journal:

Neurobiology of Aging

Year:

2011

Language:

english

File:

PDF, 3.30 MB

english, 2011

10

Regional oral absorption, hepatic first-pass effect, and non-linear disposition of salmon calcitonin in beagle dogs

Yong Hee Lee, Glen D Leesman, Vijaya Makhey, Hongshi Yu, Peidi Hu, Barbara Perry, John P Sutyak, Erik J Wagner, Lisa M Falzone, William Stern, Patrick J Sinko

Journal:

European Journal of Pharmaceutics and Biopharmaceutics

Year:

2000

Language:

english

File:

PDF, 185 KB

english, 2000

11

Accounting for Receptor Flexibility and Enhanced Sampling Methods in Computer-Aided Drug Design

Sinko, William, Lindert, Steffen, McCammon, J. Andrew

Journal:

Chemical Biology & Drug Design

Year:

2013

Language:

english

File:

PDF, 652 KB

english, 2013

12

Population Based Reweighting of Scaled Molecular Dynamics

Sinko, William, Miao, Yinglong, de Oliveira, César Augusto F., McCammon, J. Andrew

Journal:

Journal of Physical Chemistry B

Year:

2013

Language:

english

File:

PDF, 1.50 MB

english, 2013

13

A New Model For Age-Size Structure of a Population

James W. Sinko and William Streifer

Journal:

Year:

1967

Language:

english

File:

PDF, 942 KB

english, 1967

14

Exploring the role of receptor flexibility in structure-based drug discovery

Feixas, Ferran, Lindert, Steffen, Sinko, William, McCammon, J. Andrew

Journal:

Biophysical Chemistry

Year:

2014

Language:

english

File:

PDF, 1.22 MB

english, 2014

15

Undecaprenyl Diphosphate Synthase Inhibitors: Antibacterial Drug Leads

Sinko, William, Wang, Yang, Zhu, Wei, Zhang, Yonghui, Feixas, Ferran, Cox, Courtney L., Mitchell, Douglas A., Oldfield, Eric, McCammon, J. Andrew

Journal:

Journal of Medicinal Chemistry

Year:

2014

Language:

english

File:

PDF, 1.64 MB

english, 2014

16

Fast and Accurate Calculation of Small Molecule Solvation Free Energies using Replica Exchange Accelerated Molecular Dynamics

Arrar, Mehrnoosh, Sinko, William, Fajer, Mikolai, Agusto, Cesar, Oliveira, F. de, McCammon, J. Andrew

Journal:

Biophysical Journal

Year:

2012

Language:

english

File:

PDF, 35 KB

english, 2012

17

Improved Reweighting of Accelerated Molecular Dynamics Simulations for Free Energy Calculation

Miao, Yinglong, Sinko, William, Pierce, Levi, Bucher, Denis, Walker, Ross C., McCammon, J. Andrew

Journal:

Journal of Chemical Theory and Computation

Year:

2014

Language:

english

File:

PDF, 6.16 MB

english, 2014

18

w-REXAMD: A Hamiltonian Replica Exchange Approach to Improve Free Energy Calculations for Systems with Kinetically Trapped Conformations

Arrar, Mehrnoosh, de Oliveira, Cesar Augusto F., Fajer, Mikolai, Sinko, William, McCammon, J. Andrew

Journal:

Journal of Chemical Theory and Computation

Year:

2013

Language:

english

File:

PDF, 2.08 MB

english, 2013

19

Discovery of Small Molecule Inhibitors of the PH Domain Leucine-Rich Repeat Protein Phosphatase (PHLPP) by Chemical and Virtual Screening

Sierecki, Emma, Sinko, William, McCammon, J. Andrew, Newton, Alexandra C.

Journal:

Journal of Medicinal Chemistry

Year:

2010

Language:

english

File:

PDF, 4.16 MB

english, 2010

20

Protecting High Energy Barriers: A New Equation to Regulate Boost Energy in Accelerated Molecular Dynamics Simulations

Sinko, William, de Oliveira, César Augusto F., Pierce, Levi C. T., McCammon, J. Andrew

Journal:

Journal of Chemical Theory and Computation

Year:

2012

Language:

english

File:

PDF, 3.32 MB

english, 2012

21

A Molecular Dynamics Investigation of Mycobacterium tuberculosis Prenyl Synthases: Conformational Flexibility and Implications for Computer-aided Drug Discovery

Kim, Meekyum Olivia, Feng, Xinxin, Feixas, Ferran, Zhu, Wei, Lindert, Steffen, Bogue, Shannon, Sinko, William, de Oliveira, César, Rao, Guodong, Oldfield, Eric, McCammon, James Andrew

Journal:

Chemical Biology & Drug Design

Year:

2015

Language:

english

File:

PDF, 2.14 MB

english, 2015

22

Direct Evidence that Saquinavir Is Transported by Multidrug Resistance-Associated Protein (MRP1) and Canalicular Multispecific Organic Anion Transporter (MRP2)

Williams, G. C., Liu, A., Knipp, G., Sinko, P. J.

Journal:

Antimicrobial Agents and Chemotherapy

Year:

2002

Language:

english

File:

PDF, 210 KB

english, 2002

23

Applying Models Incorporating Age-Size Structure of a Population to Daphnia

James W. Sinko and William Streifer

Journal:

Year:

1969

Language:

english

File:

PDF, 835 KB

english, 1969

24

A Model for Population Reproducing by Fission

James W. Sinko and William Streifer

Journal:

Year:

1971

Language:

english

File:

PDF, 775 KB

english, 1971

25

SPIE Proceedings [SPIE High-Power Laser Ablation 2006 - Taos, NM (Sunday 7 May 2006)] High-Power Laser Ablation VI - An analysis of force generation in TEA CO 2 laser ablation of liquids

Sinko, John, Phipps, Claude R., Kodgis, Lisa, Porter, Simon, Lin, Jun, Pakhomov, Andrew V., Larson, C. William, Mead, Jr., Franklin B.

Year:

2006

Language:

english

File:

PDF, 456 KB

english, 2006

26

Elucidating the Aβ42 Anti-Aggregation Mechanism of Action of Tramiprosate in Alzheimer’s Disease: Integrating Molecular Analytical Methods, Pharmacokinetic and Clinical Data

Kocis, Petr, Tolar, Martin, Yu, Jeremy, Sinko, William, Ray, Soumya, Blennow, Kaj, Fillit, Howard, Hey, John A.

Journal:

Year:

2017

Language:

english

File:

PDF, 5.21 MB

english, 2017

27

Mathematical and Structural Characterization of Strong Non-additive SAR Caused by Protein Conformational Changes

Gomez, Laurent, Xu, Rui, Sinko, William, Selfridge, Brandon, Vernier, William Francois, Ly, Kiev, Truong, Richard, Metz, MArkus, Marrone, Tami, Sebring, Kristen, Yan, Yingzhuo, appleton, brent, Aertge

Journal:

Journal of Medicinal Chemistry

Year:

2018

Language:

english

File:

PDF, 1.25 MB

english, 2018

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